Serotonin and dopamine are key neurotransmitters that regulate mood, pleasure, motivation, sleep, appetite, and more. Serotonin promotes calm and well-being, while dopamine drives reward and motivation. Balanced levels are vital for mental and physical health. Diet, exercise, hydration, sunlight, and amino acid-rich foods like turkey, salmon, and spinach help boost these brain chemicals naturally—without relying on prescription drugs.